This Shuttle Will Self-destruct in 5 SecondsMay 13th, 2008
The US space shuttles have self-destruct systems that can be activated from the ground during the first two minutes of flight. I guess this makes sense—if the shuttle were to unexpectedly divert its course and crash in a heavily populated area, mass death and destruction would ensue. Better to destroy the shuttle and its crew. The linked article has a picture of the actual self-destruct console.